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CASPASE 8
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DeCS
Descriptor
English
:
Caspase 8
Descriptor
Spanish
:
Caspasa 8
Descriptor
Portuguese
:
Caspase 8
Tree Number:
D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.644.360.075.405.550.800
D12.776.476.075.405.550.800
Definition
English
:
A long pro-domain caspase that contains a
death
effector domain in its pro-domain region.
Caspase 8
plays a
role
in
APOPTOSIS
by cleaving and activating EFFECTOR
CASPASES
. Activation of this enzyme can occur via the interaction of its N-terminal
death
effector domain with
DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS
.
Entry Combination - descr/qualif
English
:
Caspase 8
/
antagonists & inhibitors
use
Caspase Inhibitors
Caspase 8
/
deficiency
use
Alstrom Syndrome
See Related
English
:
Autoimmune Lymphoproliferative Syndrome
History Note
English
:
2007(2000)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52227
Unique Identifier:
D053181
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS